Publication - Advice and guidance
Management of threatened miscarriage and recurrent miscarriage: guidance on use of progesterone
The Progesterone Pathway ensures that women who have had at least one previous miscarriage and present with early pregnancy bleeding are offered vaginal micronised progesterone, where it is clinically indicated, and provides guidance on asymptomatic women with four or more previous miscarriages.
Contraindications to treatment with progesterone
Therapeutic progesterone may not be suitable for those with a history of liver tumours or severe hepatic dysfunction, current genital or breast cancer, severe arterial disease, previous history of thromboembolism, jaundice relating to pregnancy, severe itch related to pregnancy, pemphigoid gestationis, acute porphyria or a previous reaction to progesterone.