Management of threatened miscarriage and recurrent miscarriage: guidance on use of progesterone
The Progesterone Pathway ensures that women who have had at least one previous miscarriage and present with early pregnancy bleeding are offered vaginal micronised progesterone, where it is clinically indicated, and provides guidance on asymptomatic women with four or more previous miscarriages.
References
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2. Coomarasamy A. et al., (2019) A randomised trial of progesterone in women with early pregnancy bleeding. N Engl J Med 380: 1815–24
3. Coomarasamy A. et al., (2020) Micronized vaginal progesterone to prevent miscarriage: a critical evaluation of randomized evidence. Am J Obstet Gynecol 223: 167–176
4. Okeke Ogwulu C.B., et al., (2020) The cost-effectiveness of progesterone in preventing miscarriages in women with early pregnancy bleeding: an economic evaluation based on the PRISM trial. BJOG 127: 757-767.
5. Wahabi H.A. et al., (2018) Progestogen for treating threatened miscarriage. Cochrane Database Syst Rev 2018: CD005943
6. Devall A.J. et al., (2021) Progestagens for preventing miscarriage: a network meta-analysis. Cochrane Database Syst Rev 2021: CD013792
7. Coomarasamy A. et al., (2015) A randomized trial of progesterone in women with recurrent miscarriages. N Engl J Med 373: 2141–48.
8. Haas DM et al., (2019) Progestogen for preventing miscarriage in women with recurrent miscarriage of unclear etiology. Cochrane Database Syst Rev 2019; 11: CD003511.
9. Tommy’s UK Early pregnancy bleeding and progesterone poster. Early pregnancy bleeding and progesterone guide V3
10. Utrogestan vaginal 200mg capsules. https://www.medicines.org.uk/emc/product/3244/smpc. Updated Feb 2020. Accessed 15/07/2020.
11. Cyclogest 400mg pessaries. https://www.medicines.org.uk/emc/product/5569/smpc. Updated Nov 2019. Accessed 15/07/2020.
12. Ectopic pregnancy and miscarriage: diagnosis and initial management. NICE guideline 126. https://www.nice.org.uk/guidance/ng126/. Accessed 01/12/2021.
13. Regan L et al., RCOG Green-Top Guideline No. 17 Recurrent Miscarriage. BJOG 130: e9-e39. Recurrent Miscarriage (Green-top Guideline No. 17) | RCOG