Publication - Advice and guidance
Management of threatened miscarriage and recurrent miscarriage: guidance on use of progesterone
The Progesterone Pathway ensures that women who have had at least one previous miscarriage and present with early pregnancy bleeding are offered vaginal micronised progesterone, where it is clinically indicated, and provides guidance on asymptomatic women with four or more previous miscarriages.
Effects of progesterone on fetal development
Women should be made aware that there are no current concerns for the mother or unborn baby from existing evidence and as per the NICE guidelines. However, there is overall limited evidence available and there is no evidence on the long-term effects on babies of using progesterone supplementation in the first 16 weeks of pregnancy. The discussion should be documented in the Electronic Patient Record (EPR).