# Coronavirus (COVID-19): modelling the epidemic (issue no.77)

Latest findings in modelling the COVID-19 epidemic in Scotland, both in terms of the spread of the disease through the population (epidemiological modelling) and of the demands it will place on the system, for example in terms of health care requirement.

## Technical Annex

Epidemiology is the study of how diseases spread within populations. One way we do this is using our best understanding of the way the infection is passed on and how it affects people who catch it to create mathematical simulations. Because people who catch Covid-19 have a relatively long period in which they can pass it on to others before they begin to have symptoms, and the majority of people infected with the virus will experience mild symptoms, this "epidemiological modelling" provides insights into the epidemic that cannot easily be measured through testing e.g. of those with symptoms, as it estimates the total number of new daily infections and infectious people, including those who are asymptomatic or have mild symptoms.

Modelling also allows us to make short-term forecasts of what may happen with a degree of uncertainty. These can be used in health care and other planning. The modelling in this research findings is undertaken using different types of data which going forward aims to both model the progress of the epidemic in Scotland and provide early indications of where any changes are taking place.

The delivery of the vaccination programme will offer protection against severe disease and death. The modelling includes assumptions about compliance with restrictions and vaccine take-up. Work is still ongoing to understand how many vaccinated people might still spread the virus if infected. As Covid-19 is a new disease there remain uncertainties associated with vaccine effectiveness. Furthermore, there is a risk that new variants emerge for which immunisation is less effective.

### How the modelling compares to the real data as it emerges

The following charts show the history of our modelling projections in comparison to estimates of the actual data. The infections projections were largely accurate during October to mid-December 2020 and from mid‑January 2021 onwards. During mid-December 2020 to mid‑January 2021, the projections underestimated the number of infections, due to the unforeseen effects of the new variant.

Hospital bed projections have generally been more precise than infections estimates due to being partially based on already known information about numbers of current infections, and number of people already in hospital. The projections are for number of people in hospital due to Covid-19, which is slightly different to the actuals, which are number of people in hospital within 28 days of a positive Covid-19 test.

As with hospital beds, ICU bed projections have generally been more precise than infections. The projections are for number of people in ICU due to Covid-19. The actuals are number of people in ICU within 28 days of a positive Covid-19 test up to 20 January 2021, after which they include people in ICU over the 28 day limit.

Table 1. Probability of local authority areas exceeding thresholds of cases per 100K (21st to 27th November 2021), data to 8th November.
Probability of exceeding (cases per 100K)
Local Authority (LA) 50 100 300 500
Aberdeen City 75-100% 75-100% 25-50% 5-15%
Aberdeenshire 75-100% 75-100% 15-25% 0-5%
Angus 75-100% 75-100% 25-50% 25-50%
Argyll and Bute 75-100% 75-100% 25-50% 15-25%
City of Edinburgh 75-100% 50-75% 25-50% 5-15%
Clackmannanshire 75-100% 75-100% 50-75% 25-50%
Dumfries & Galloway 75-100% 75-100% 25-50% 25-50%
Dundee City 75-100% 75-100% 25-50% 5-15%
East Ayrshire 75-100% 75-100% 50-75% 25-50%
East Dunbartonshire 75-100% 75-100% 25-50% 15-25%
East Lothian 75-100% 75-100% 25-50% 15-25%
East Renfrewshire 75-100% 75-100% 25-50% 15-25%
Falkirk 75-100% 75-100% 25-50% 15-25%
Fife 75-100% 75-100% 25-50% 5-15%
Glasgow City 75-100% 50-75% 25-50% 15-25%
Highland 75-100% 75-100% 25-50% 15-25%
Inverclyde 75-100% 75-100% 25-50% 25-50%
Midlothian 75-100% 75-100% 25-50% 5-15%
Moray 75-100% 75-100% 25-50% 15-25%
Na h-Eileanan Siar 75-100% 50-75% 15-25% 0-5%
North Ayrshire 75-100% 75-100% 25-50% 15-25%
North Lanarkshire 75-100% 75-100% 25-50% 15-25%
Orkney Islands 50-75% 50-75% 15-25% 0-5%
Perth and Kinross 75-100% 75-100% 25-50% 25-50%
Renfrewshire 75-100% 75-100% 25-50% 15-25%
Scottish Borders 75-100% 75-100% 25-50% 15-25%
Shetland Islands 25-50% 5-15% 0-5% 0-5%
South Ayrshire 75-100% 75-100% 25-50% 15-25%
South Lanarkshire 75-100% 75-100% 50-75% 25-50%
Stirling 75-100% 75-100% 25-50% 15-25%
West Dunbartonshire 75-100% 75-100% 25-50% 15-25%
West Lothian 75-100% 75-100% 25-50% 15-25%

### What levels of Covid-19 are indicated by wastewater data?

Table 2 provides population weighted daily averages for normalised WW Covid-19 levels in the weeks beginning 27th October and 3rd November 2021, with no estimate for error. This is given in Million gene copies per person, which approximately corresponds to new cases per 100,000 per day. Coverage is given as percentage of LA inhabitants covered by a wastewater Covid‑19 sampling site delivering data during this period[11].

Table 2. Average daily cases per 100k as given by WW data [12].
Local authority (LA) w/b 27th October w/b 3rd November Coverage
Aberdeen City 64 91.4 99 %
Aberdeenshire 108 58.0 37 %
Angus 83 41.6 68 %
Argyll and Bute 3 %
City of Edinburgh 52 66.6 98 %
Clackmannanshire 188 85.8 92 %
Dumfries & Galloway 90 62.9 39 %
Dundee City 77 38.4 100 %
East Ayrshire 70 137.2 72 %
East Dunbartonshire 57 78.5 99 %
East Lothian 53 61.6 74 %
East Renfrewshire 41 54.0 95 %
Falkirk 62 57.4 96 %
Fife 90 56.8 84 %
Glasgow City 49 63.4 75 %
Highland 94 26.5 31 %
Inverclyde 11 51.8 98 %
Midlothian 61 66.7 73 %
Moray 44 81.6 14 %
Na h-Eileanan Siar 0 %
North Ayrshire 40 33.5 93 %
North Lanarkshire 52 44.1 91 %
Orkney Islands 17 25.3 34 %
Perth and Kinross 114 79.2 38 %
Renfrewshire 31 52.9 97 %
Scottish Borders 128 46.8 59 %
Shetland Islands 0.6 29 %
South Ayrshire 62 67.4 77 %
South Lanarkshire 52 57.3 90 %
Stirling 42 23.9 63 %
West Dunbartonshire 60 68.3 98 %
West Lothian 119 88.3 95 %