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Virology

Infectious salmon anaemia (ISAV):

An orthomyxovirus causing the disease termed infectious salmon anaemia affecting sea-farmed Atlantic salmon (Salmo salar).  ISAV is an enveloped virus consisting of 8 single-stranded RNA segments.

Characterised by severe anaemia, haemorrhaging and necrosis. Clinical signs include pale gills, exophthamia, distended abdomen and sometimes haemorrhages.

The diagnostic methods include:

  • Virus Isolation
  • Immunofluorescence antibody test (IFAT)
  • Immunohistochemistry (ISA IHC)
  • Molecular and sequencing

More information:

 

 

Cytopathic effect (CPE) of ISAV

Cytopathic effect (CPE) of ISAV

 

A Haemadsorption test
 

and a Haemadsorption test 
confirming the presence of ISAV virus
on TO cell lines

 

 

ISA IHC positive result in heart tissue

ISA IHC positive result in heart tissue

 

an IFAT positive result for ISAV

an IFAT positive result for ISAV